The Mesothelioma Society » Clinical Trials

How to Participate in Mesothelioma Clinical Trials

admin — Mon, 02 Jun 2008 23:15:39 +0000

Most oncologists (cancer doctors) specializing in the treatment of mesothelioma will be aware of the clinical trials that are in process or about to get underway and that are seeking patients who are fighting mesothelioma.

If you are a candidate, you should know that there are basically 4 types of clinical trials:

Treatment trials - testing new approaches to cancer treatment, be it a drug, radiation therapy, multi-modal therapy, or a totally new treatment procedure.
Prevention trials – testing new approaches to lowering the risk of developing a certain kind of cancer.
Screening trials – testing new ways to detect cancer, particularly in its early stages. These are important trials in the field of mesothelioma, which is usually diagnosed in its late stages.
Supportive care trials – testing ways to improve comfort and quality of life for cancer patients, often referred to as palliative treatments.

Patients can be involved in various phases of a trial:

Phase I helps determine how a new drug should be given and attempts to measure safe dosage. This phase generally involves only a handful of volunteers.
Phase II trials usually focus on one particular type of cancer and are used to test the safety of the drug and how well it works in combating a particular cancer.
Phase III trials test new drugs or treatments in comparison with the current standard. In a process called randomization, the participant will be assigned to the standard group or the new drug/treatment group. Phase III trials are the largest and may often involve doctors and hospitals throughout the country.

Your doctor can best determine if you are a candidate for any ongoing trials and will take the responsibility of submitting the proper paperwork for consideration. Don’t be afraid to ask about participation in any type of clinical trials or inquire about one of which you may be aware.

Pemetrexed Disodium and Either Gemcitabine or Carboplatin in Treating Patients With Advanced Malignant Pleural Mesothelioma

admin — Mon, 02 Jun 2008 12:53:56 +0000

Sponsored by:	Eastern Cooperative Oncology Group
Information provided:	National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:	NCT00101283
Condition	Malignant Mesothelioma
Intervention	Drug: carboplatin Drug: gemcitabine hydrochloride Drug: pemetrexed disodium Procedure: chemotherapy
Phase	Phase 2

Purpose:

This randomized phase II trial is studying pemetrexed disodium and gemcitabine to see how well they work compared to pemetrexed disodium and carboplatin in treating patients with advanced malignant pleural mesothelioma.

RATIONALE: Drugs used in chemotherapy, such as pemetrexed disodium, gemcitabine, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known whether giving pemetrexed disodium with gemcitabine is more effective than giving pemetrexed disodium with carboplatin in treating malignant pleural mesothelioma.

Eligibility

Study Design: Treatment, Randomized, Active Control

Official Title: Pemetrexed Plus Gemcitabine Or Carboplatin In Patients With Advanced Malignant Mesothelioma: A Randomized Phase II Trial

Enrollment Size: Both

Gender: 18 Years

Min. Age: N/A

Max. Age:

Location and Contact Information

The following is a list of clinial trials centers by state currently in process in the search for the treament and cure of mesothelioma. If you are a mesothelioma patient, please contact your doctor for more information about these trials.

United States, Connecticut
Eastern Connecticut Hematology and Oncology Associates, Norwich, Connecticut, 06360, United States

United States, Delaware
CCOP – Christiana Care Health Services, Newark, Delaware, 19713, United States

United States, Delaware
Tunnell Cancer Center at Beebe Medical Center, Lewes, Delaware, 19958, United States

United States, Florida
Mayo Clinic – Jacksonville, Jacksonville, Florida, 32224, United States

United States, Georgia
Winship Cancer Institute of Emory University, Altanta, Georgia, 30322, United States

United States, Illinois
BroMenn Regional Medical Center, Normal, Illinois, 61761, United State

United States, Illinois
Cancer Treatment Center at Pekin Hospital, Pekin, Illinois, 61554, United States

United States, Illinois
Carle Cancer Center at Carle Foundation Hospital, Urbana, Illinois, 61801, United States

United States, Illinois
CCOP – Carle Cancer Center, Urbana, Illinois, 61801, United States

United States, Illinois
CCOP – Illinois Oncology Research Association, Peoria, Illinois, 61615, United States

United States, Illinois
Community Cancer Center, Normal, Illinois, 61761, United States

United States, Illinois
Community Hospital of Ottawa, Ottawa, Illinois, 61350, United States

United States, Illinois
Decatur Memorial Hospital Cancer Care Institute, Decatur, Illinois, 62526, United States

United States, Illinois
Eureka Community Hospital, Eureka, Illinois, 61530, United States

United States, Illinois
Galesburg Clinic, PC, Galesburg, Illinois, 61401, United States

United States, Illinois
Galesburg Cottage Hospital, Galesburg, Illinois, 61401, United States

United States, Illinois
Graham Hospital, Canton, Illinois, 61520, United States

United States, Illinois
Hopedale Medical Complex, Hopedale, Illinois, 61747, United States

United States, Illinois
Illinois Valley Community Hospital, Peru, Illinois, 61354, United States

United States, Illinois
Joliet Oncology-Hematology Associates, Limited – West, Joliet, Illinois, 60435, United States

United States, Illinois
Kewanee Hospital, Kewanee, Illinois, 61443, United States

United States, Illinois
Mason District Hospital, Havana, Illinois, 62644, United States

United States, Illinois
McDonough District Hospital, Macomb, Illinois, 61455, United States

United States, Illinois
Memorial Hospital, Carthage, Illinois, 62321, United States

United States, Illinois
Methodist Medical Center of Illinois, Peoria, Illinois, 61636, United States

United States, Illinois
Oncology Hematology Associates of Central Illinois, PC – Ottawa, Ottawa, Illinois, 61350, United States

United States, Illinois
Oncology Hematology Associates of Central Illinois, PC – Peoria, Peoria, Illinois, 61615, United States

United States, Illinois
OSF St. Francis Medical Center, Peoria, Illinois, 61637, United States

United States, Illinois
Perry Memorial Hospital, Princeton, Illinois, 61356, United States

United States, Illinois
Proctor Hospital, Peoria, Illinois, 61614, United States

United States, Illinois
Regional Cancer Center at Memorial Medical Center, Springfield, Illinois, 62781-0001, United States

United States, Illinois
Rush-Copley Cancer Care Center, Aurora, Illinois, 60504, United States

United States, Illinois
St. Joseph Medical Center, Bloomington, Illinois, 61701, United States

United States, Illinois
St. Margaret’s Hospital, Spring Valley, Illinois, 61362, United States

United States, Illinois
Trinity Cancer Center at Trinity Medical Center – 7th Street Campus, Moline, Illinois, 61265, United States

United States, Indiana
CCOP – Northern Indiana CR Consortium, South Bend, Indiana, 46601, United States

United States, Indiana
Center for Cancer Therapy at LaPorte Hospital and Health Services, La Porte, Indiana, 46350, United States

United States, Indiana
Elkhart General Hospital, Elkhart, Indiana, 46515, United States

United States, Indiana
Howard Community Hospital, Kokomo, Indiana, 46904, United States

United States, Indiana
Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, 46202-5289, United States

United States, Indiana
Memorial Hospital of South Bend, South Bend, Indiana, 46601, United States

United States, Indiana
Saint Anthony Memorial Health Centers, Michigan City, Indiana, 46360, United States

United States, Indiana
Saint Joseph Regional Medical Center, South Bend, Indiana, 46617, United States

United States, Indiana
Veterans Affairs Medical Center – Indianapolis, Indianapolis, Indiana, 46202, United States

United States, Indiana
William N. Wishard Memorial Hospital, Indianapolis, Indiana, 46202, United States

United States, Iowa

Cedar Rapids Oncology Associates, Cedar Rapids, Iowa, 52403, United States

United States, Iowa
McFarland Clinic, PC, Ames, Iowa, 50010, United States

United States, Iowa
Mercy Medical Center – Sioux City, Sioux City, Iowa, 51104, United States

United States, Iowa
Siouxland Hematology-Oncology Associates, LLP, Sioux City, Iowa, 51101, United States

United States, Iowa
St. Luke’s Regional Medical Center, Sioux City, Iowa, 51104, United States

United States, Maryland
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, 21231-2410, United States

United States, Maryland
Union Hospital Cancer Program at Union Hospital, Elkton MD, Maryland, 21921, United States

United States, Michigan
Borgess Medical Center, Kalamazoo, Michigan, 49001, United States

United States, Michigan
Bronson Methodist Hospital, Kalamazoo, Michigan, 49007, United States

United States, Michigan
CCOP – Michigan Cancer Research Consortium, Ann Arbor, Michigan, 48106, United States

United States, Michigan
Foote Memorial Hospital, Jackson, Michigan, 49201, United States

United States, Michigan
Genesys Hurley Cancer Institute, Flint, Michigan, 48503, United States

United States, Michigan
Hurley Medical Center, Flint, Michigan, 48503, United States

United States, Michigan
Lakeland Regional Cancer Care Center – St. Joseph, St. Joseph, Michigan, 49085, United States

United States, Michigan
Oakwood Cancer Center at Oakwood Hospital and Medical Center, Dearborn, Michigan, 48123-2500, United States

United States, Michigan
Saint Joseph Mercy Cancer Center, Ann Arbor, Michigan, 48106-0995, United States

United States, Michigan
Seton Cancer Institute at Saint Mary’s – Saginaw, Saginaw, Michigan, 48601, United States

United States, Michigan
Sparrow Regional Cancer Center, Lansing, Michigan, 48912-1811, United States

United States, Michigan
St. John Macomb Hospital, Warren, Michigan, 48093, United States

United States, Michigan
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods, Michigan, 48236, United States

United States, Michigan
West Michigan Cancer Center, Kalamazoo, Michigan, 49007-3731, United States

United States, Minnesota
CCOP – Duluth, Duluth, Minnesota, 55805, United States

United States, Minnesota
CCOP – Metro-Minnesota, Saint Louis Park, Minnesota, 55416, United States

United States, Minnesota
Duluth Clinic Cancer Center – Duluth, Duluth, Minnesota, 55805-1983, United States

United States, Minnesota
Fairview Ridges Hospital, Burnsville, Minnesota, 55337, United States

United States, Minnesota
Fairview Southdale Hospital, Edina, Minnesota, 55435, United States

United States, Minnesota
HealthEast Cancer Care at St. John’s Hospital, Maplewood, Minnesota, 55109, United States

United States, Minnesota
HealthEast Cancer Care at St. Joseph’s Hospital, St Paul, Minnesota, 55102, United States

United States, Minnesota
HealthEast Cancer Care at Woodwinds Health Campus, Woodbury, Minnesota, 55125, United States

United States, Minnesota
Hennepin County Medical Center – Minneapolis, Minneapolis, Minnesota, 55415, United States

United States, Minnesota
Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale, Minnesota, 55422-2900, United States

United States, Minnesota
Hutchinson Area Health Care, Hutchinson, Minnesota, 55350, United States

United States, Minnesota
Mayo Clinic Cancer Center, Rochester, Minnesota, 55905, United States

United States, Minnesota
Meeker County Memorial Hospital, Lichfield, Minnesota, 55355, United States

United States, Minnesota
Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids, Minnesota, 55433, United States

United States, Minnesota
Mercy and Unity Cancer Center at Unity Hospital, Fridley, Minnesota, 55432, United States

United States, Minnesota
Miller – Dwan Medical Center, Duluth, Minnesota, 55805, United States

United States, Minnesota
Minnesota Oncology Hematology, PA – Maplewood, Maplewood, Minnesota, 55109, United States

United States, Minnesota
Minnesota Oncology Hematology, PA – Woodbury, Woodbury, Minnesota, 55125, United States

United States, Minnesota
Park Nicollet Cancer Center, St. Louis Park, Minnesota, 55416, United States

United States, Minnesota
Regions Hospital Cancer Care Center, St. Paul, Minnesota, 55101, United States

United States, Minnesota
Ridgeview Medical Center, Waconia, Minnesota, 55387, United States

United States, Minnesota
St. Francis Cancer Center at St. Francis Medical Center, Shakopee, Minnesota, 55379, United States

United States, Minnesota
United Hospital, St. Paul, Minnesota, 55102, United States

United States, Minnesota
Virginia Piper Cancer Institute at Abbott – Northwestern Hospital, Minneapolis, Minnesota, 55407, United States

United States, New Jersey
Cancer Institute of New Jersey at Cooper – Voorhees, Voorhees, New Jersey, 08043, United States

United States, New Jersey
Cancer Institute of New Jersey at UMDNJ – Robert Wood Johnson Medical School, New Brunswick, New Jersey, 08903, United States

United States, New Jersey
CCOP – Northern New Jersey, Hackensack, New Jersey, 07601, United States

United States, New Jersey
Fox Chase Virtua Health Cancer Program at Virtua West Jersey, Voorhees, New Jersey, 08043, United States

United States, New Jersey
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton, Marlton, New Jersey, 08053, United States

United States, New Jersey
Veterans Affairs Medical Center – East Orange, East Orange, New Jersey, 07018-1095, United States

United States, North Dakota
Bismarck Cancer Center, Bismarck, North Dakota, 58501, United States

United States, North Dakota
Medcenter One Hospital Cancer Care Center, Bismarck, North Dakota, 58501, United States

United States, North Dakota
Mid Dakota Clinic, PC, Bismarck, North Dakota, 58501, United States

United States, North Dakota
St. Alexius Medical Center Cancer Center, Bismarck, North Dakota, 58502, United States

United States, Ohio
Aultman Cancer Center at Aultman Hospital, Canton, Ohio, 44710-1799, United States

United States, Ohio
Case Comprehensive Cancer Center, Cleveland, Ohio, 44106-5065, United States

United States, Ohio
St. Rita’s Medical Center, Lima, Ohio, 45801, United States

United States, Ohio
Summa Center for Cancer Care at Akron City Hospital, Akron, Ohio, 44309-2090, United States

United States, Pennsylvania
Albert Einstein Cancer Center, Philadelphia, Pennsylvania, 19141, United States

United States, Pennsylvania
Fox Chase Cancer Center – Philadelphia, Philadelphia, Pennsylvania, 19111-2497, United States

United States, Pennsylvania
Lewistown Hospital, Lewistown, Pennsylvania, 17044, United States

United States, Pennsylvania
Morgan Cancer Center at Lehigh Valley Hospital – Cedar Crest, Allentown, Pennsylvania, 18105, United States

United States, Pennsylvania
Mount Nittany Medical Center, State College, Pennsylvania, 16803, United States

United States, Pennsylvania
Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey, Pennsylvania, 17033-0850, United States

United States, South Dakota
Avera Cancer Institute, Sioux Falls, South Dakota, 57105, United States

United States, South Dakota
Medical X-Ray Center, PC, Sioux Falls, South Dakota, 57105, United States

United States, South Dakota
Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls, South Dakota, 57117-5039, United States

United States, Wisconsin
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center, La Crosse, Wisconsin, 54601, United States

United States, Wisconsin
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison, Wisconsin, 53792-6164, United States

Immunotoxin Therapy, Pemetrexed, and Cisplatin in Treating Patients With Malignant Pleural Mesothelioma That Cannot Be Removed by Surgery

admin — Mon, 02 Jun 2008 03:01:20 +0000

This study is currently recruiting patients.

Sponsored by:	National Cancer Institute (NCI)
Information provided:	National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:	NCT00575770
Condition	Malignant Mesothelioma
Intervention	Drug: SS1(dsFv)-PE38 immunotoxin Drug: cisplatin Drug: pemetrexed disodium Procedure: chemotherapy Procedure: immunoenzyme technique Procedure: immunohistochemistry staining method Procedure: immunotoxin therapy Procedure: pharmacological study Procedure: quality-of-life assessment
Phase	Phase 1

Purpose:

This phase I trial is studying the side effects and best dose of immunotoxin therapy when given together with pemetrexed and cisplatin in treating patients with malignant pleural mesothelioma that cannot be removed by surgery.

RATIONALE: Immunotoxins can find tumor cells and kill them without harming normal cells. Drugs used in chemotherapy, such as pemetrexed and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) together with immunotoxin therapy may kill more malignant mesothelioma cells.

Eligibility

Study Design: Treatment, Non-Randomized, Open Label, Active Control

Official Title: A Phase I, Single Center, Dose-Escalation Study of SS1(dsFv)PE38 Administered Concurrently With Pemetrexed and Cisplatin in Subjects With Unresectable Malignant Epithelial Pleural Mesothelioma

Enrollment Size: Both

Gender: 18 Years

Min. Age: N/A

Max. Age:

Location and Contact Information

United States, Maryland
Warren Grant Magnuson Clinical Center – NCI Clinical Trials Referral Office, Bethesda, Maryland, 20892-1182, United States
Status: Recruiting
Clinical Trials Office – Warren Grant Magnusen Clinical Center 888-NCI-1937

Actively Recruiting:

The following is a list of clinial trials currently in process in the search for the treament and cure of mesotheilioma. If you are a mesotheilioma patient, please contact your doctor for more information about these trials.

Trial: Cisplatin, Imatinib Mesylate, and Pemetrexed in Malignant Mesothelioma Patients

Conditions: Mesothelioma

Trial: Immunotoxin Therapy, Pemetrexed, and Cisplatin in Treating Patients With Malignant Pleural Mesothelioma That Cannot Be Removed by Surgery